This piece, Game Over, was appropriated from Michelangelo's La Pieta. The original meaning of La Pieta was to show the connection and emotion between Christ and his mother. It was a religious symbol.
Game Over has been appropriated by exchanging Mary and Jesus with Princess Peach and Mario of Super Mario Brothers fame. I think the appropriation can be interpreted by saying that the digital world has become like a religion. Instead of worshiping God, people begin to worship worldly objects like video games, movies, and music.
This is a Coca-Cola ad from the early 1900's with the slogan "Thirst Knows No Season":
And this is my appropriation of it: